New Alarming Disease: Fungal Disease Outbreak Here

Is this deadly fungal disease linked with covid? Is this infection spread to whom effect it? You and your doctor can recognize the symptoms of a fungal disease early and may help prevent serious complications.Copyright © 2020 Ubiquity Press. All rights reserved.

Influencing Factors and Symbiotic Mechanism of the Integration of Medical Care and Disease Prevention during the COVID-19 Pandemic: A Cross-Sectional Survey of Public Hospital Employees.

Background: The COVID-19 outbreak has accelerated the huge difference between medical care and disease prevention in Chinese medical institutions. This study aimed to investigate the relationship between the symbiotic units, environments, models, and effects of the integration of medical care and disease prevention. Methods: This cross-sectional study involved 762 employees of public hospitals in 11 cities in Zhejiang Province by random stratified sampling. We analyzed the influence paths of elements in the mechanism of integration of medical care and disease prevention and the mediating effect of symbiotic models among symbiotic units, symbiotic environments, and effects on this integration. Results: The path coefficient of the symbiotic unit on the symbiosis model was 0.46 (p < 0.001), the path coefficient of the symbiotic environment on the symbiosis model was 0.52 (p < 0.001). The path coefficient of the symbiotic unit and the environment was 0.91 (p < 0.001). The symbiotic models exhibited a partial mediation effect between symbiotic units and the effect of this integration. Sobel test = 3.27, ß = 0.152, and the mediating effect accounted for 34.6%. Conclusions: It is suggested that health policymakers and public hospital managers should provide sufficient symbiotic units, establish collaborative symbiotic models, and improve the effects of integration of medical care and disease prevention in public hospitals.

Significant alterations of intestinal symbiotic microbiota induced by intraperitoneal vaccination mediate changes in intestinal metabolism of NEW Genetically Improved Farmed Tilapia (NEW GIFT, Oreochromis niloticus).

BACKGROUND: After millions of years of coevolution, symbiotic microbiota has become an integral part of the host and plays an important role in host immunity, metabolism, and health. Vaccination, as an effective means of preventing infectious diseases, has been playing a vital role in the prevention and control of human and animal diseases for decades. However, so far, minimal is known about the effect of vaccination on fish symbiotic microbiota, especially mucosal microbiota, and its correlation with intestinal metabolism remains unclear. METHODS: Here we reported the effect of an inactivated bivalent Aeromonas hydrophila/Aeromonas veronii vaccine on the symbiotic microbiota and its correlation with the intestinal metabolism of farmed adult Nile tilapia (Oreochromis niloticus) by 16S rRNA gene high-throughput sequencing and gas chromatography-mass spectrometry metabolomics. RESULTS: Results showed that vaccination significantly changed the structure, composition, and predictive function of intestinal mucosal microbiota but did not significantly affect the symbiotic microbiota of other sites including gill mucosae, stomach contents, and stomach mucosae. Moreover, vaccination significantly reduced the relative abundance values of potential opportunistic pathogens such as Aeromonas, Escherichia-Shigella, and Acinetobacter in intestinal mucosae. Combined with the enhancement of immune function after vaccination, inactivated bivalent Aeromonas vaccination had a protective effect against the intestinal pathogen infection of tilapia. In addition, the metabolite differential analysis showed that vaccination significantly increased the concentrations of carbohydrate-related metabolites such as lactic acid, succinic acid, and gluconic acid but significantly decreased the concentrations of multiple lipid-related metabolites in tilapia intestines. Vaccination affected the intestinal metabolism of tilapia, which was further verified by the predictive function of intestinal microbiota. Furthermore, the correlation analyses showed that most of the intestinal differential microorganisms were significantly correlated with intestinal differential metabolites after vaccination, confirming that the effect of vaccination on intestinal metabolism was closely related to the intestinal microbiota. CONCLUSIONS: In conclusion, this paper revealed the microbial and metabolic responses induced by inactivated vaccination, suggesting that intestinal microbiota might mediate the effect of vaccination on the intestinal metabolism of tilapia. It expanded the novel understanding of vaccine protective mechanisms from microbial and metabolic perspectives, providing important implications for the potential influence of vaccination on human intestinal microbiota and metabolism. Video Abstract.

Symbiotic microbiota: A class of potent immunomodulators

Microbiome is known to exist as symbiotic commensals in humans, domestic and wild animals, birds, fishes, reptiles, insects etc. DNA sequencing and metagenomic platforms have deciphered the complex role played by communities of microbiota (bacteria, fungi, viruses, protozoa and other eukaryotic species) in survival and regulation of host physiology, metabolism and regulation of host immune system. Any alteration in the microbial population or breach in the symbiotic alliance with the host may ultimately lead to development of different kinds of pathologies. Realization of the enormous role played by the microbiome in health and diseases of human and domestic livestock led researchers to find ways to modulate these resident microbiomes for improvement in health and management of diseases. Theoretically there are several ways that can be employed for manipulating the composition and functional capacity of the resident microbiome, which may lead to improvements in human and livestock health. Though studies have shown therapeutic potential of the microbiome, considerable challenges exist in the actual implementation of these strategies in clinical settings. This review discusses the symbiotic relationship between microbiome and host and strategies to modulate host immune responses by manipulating microbiome profile. Paper also highlights how to overcome existing obstacles for successful implementation of microbiome manipulation techniques. In this era of COVID-19, it would be worth analysing the role of resident microbiome in the magnitude of COVID-19 severity which may have occurred through immunomodulation.

A Simulation Optimization for Location and Allocation of Emergency Medical Service

Emergency medical services are an essential element in the modern healthcare system. Health care services are the most important because they play an important role in saving people's lives and reducing rates of mortality and morbidity. Especially during the covid-19 pandemic and the new normal era makes this problem very interesting to discuss. For this reason, this study tries to overcome the problem location and allocation of Emergency Medical Services (EMS) by using a combination of metaheuristics and simulation. The approach taken to overcome these challenges is developing Symbiotic Organisms Search algorithm and then use the simulation method to validation the result. The transition of the ambulance system from a centralized to decentralized system by using the Modification of Symbiotic Organisms Searrch (Mod-SOS) algorithm, found that to shorten the response time to 9 minutes, need to combine the 5 core bases with about 12 potential bases. From the simulation scenarios tested, the total number of ambulances involved in the proposed system is 16 units. So it can be concluded that involving several potential bases can produce a short response time © 2022, International journal of online and biomedical engineering.All Rights Reserved.

Sustainable Tourism as a Driving Factor for Competitiveness in the Olive Sector

Tourism is facing serious difficulties worldwide due to the global pandemic COVID-19, translating considerably into an industry effort to compete in the marketplace. In effect, sustainable tourism is considered to have a symbiotic relationship with competitiveness that will allow organisations to make a difference. This means that the sustainability factors are positively related to the competitiveness indicators. In this context, as the oliviculture sector faces challenges in a changing market in terms of ecological, demographic, and consumption practices changes, it is considered that sustainable tourism will enable the sector to make a difference. For, the environmental and social changes of the stakeholders enhance the promotion of sustainability to meet their needs, which in turn increases the sector's competitive advantage. In this respect, the present study was based on a literature review consolidated in a bibliometric analysis to analyse sustainable tourism as a driver of competitiveness in the oliviculture industry. For this purpose, the Scopus database was used, in which 157 full articles published until September 2021 were obtained. Based on the results, using the Bibliometrix R, it was found that research in this field has emerged in the last 20 years and focuses particularly on the terms “competitiveness”, “ecotourism” and “tourism development”. In addition, the countries with the highest scientific production and citations, the main sources of publication in this field of research, the documents with the most citations as well as the co-citations between authors were analysed. Through bibliometric analysis, it is possible to provide researchers, policy-makers and managers with a current view of the undoubted role that sustainable tourism plays in the competitiveness of the olive sector. Considering the trends, it is therefore expected to contribute bases for future strategies aimed at overcoming obstacles, overcoming challenges, and seizing opportunities for a more competitive sector. © 2022 IEEE Computer Society. All rights reserved.

Kombucha - An ancient fermented beverage with desired bioactivities: A narrowed review.

Kombucha, originated in China 2000  years ago, is a sour and sweet-tasted drink, prepared traditionally through fermentation of black tea. During the fermentation of kombucha, consisting of mainly acidic compounds, microorganisms, and a tiny amount of alcohol, a biofilm called SCOBY forms. The bacteria in kombucha has been generally identified as Acetobacteraceae. Kombucha is a noteworthy source of B complex vitamins, polyphenols, and organic acids (mainly acetic acid). Nowadays, kombucha is tended to be prepared with some other plant species, which, therefore, lead to variations in its composition. Pre-clinical studies conducted on kombucha revealed that it has desired bioactivities such as antimicrobial, antioxidant, hepatoprotective, anti-hypercholestorelomic, anticancer, anti-inflammatory, etc. Only a few clinical studies have been also reported. In the current review, we aimed to overhaul pre-clinical bioactivities reported on kombucha as well as its brief compositional chemistry. The literature data indicate that kombucha has valuable biological effects on human health.

Covid-19 global pandemic, workplace spirituality and the rise of spirituality-driven organisations in the post-digital era

Purpose>Despite the growing importance of workplace spirituality, organisations have been reluctant to integrate spirituality into their workplaces;this paper discusses how to integrate spirituality into the workplace.Design/methodology/approach>This is a theoretical paper that builds its arguments on the synthesis of workplace spirituality and contemporary management paradigms.Findings>The study argues that workplace spirituality is an extremely important driving force for the sustainable and healthy growth of any organisation;however, infusing workplace spirituality into companies in the industrial and digital eras would be a futile effort, as industrial organisations are built on an ethos highly incongruent with spiritual principles. Therefore, in the post-digital era, spirituality-driven organisations (SDOs) will emerge, marking the beginning of a true “spiritual paradigm” for business and human society at large. The study also elaborates on the characteristics of the post-digital era and the nature of SDOs.Originality/value>Workplace spirituality has been a research topic for years but has never gained sufficient momentum. The Covid-19 global pandemic has made workplace spirituality a more pertinent issue on corporate agendas. Therefore, this paper provides the theoretical foundation to embed workplace spirituality in contemporary management thoughts and practices.

Redefining public health and sustainable economy: Covid-19 from pandemic to endemic.

With the recent claim that the maintenance of population immunity will not depend on continued vaccinations but on the endemic presence of the virus, the proper understanding of the value of public health allows us to configure human living conditions as it thrives in a world where the novel Corona Virus Disease in 2019 (Covid-19) becomes endemic. World leaders and economic managers need to redefine public health not just as a means that enables economic productivity but as a substantially primordial goal-an end that every functional society must achieve via living an economically sustainable lifestyle. This paper argues that economic and societal sustainability thus must be framed and delimited within the human ecological boundary-a crucial viewpoint that could sustain public health amid a Covid-19 endemic world while preventing another viral pandemic from occurring.